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Paroxetine paroxetine

How to take this antidepressant

Paroxetine is taken orally once a day, preferably in the morning. Ideally, do this with meals to reduce the chance of side effects such as vomiting and nausea. The tablet is washed down with a small amount of water..

Like other antidepressants, Paroxetine requires a long course of therapy. The duration of treatment with this drug starts from 6 weeks and can last up to 6 months..

Some patients are prescribed a constant maintenance dose in minimal amounts (in cases where it is impossible to refuse the medication).

Dosage of the drug depending on the disease:

  1. In depressive disorders, the minimum daily dose of the drug is 10 mg. The optimal dose of the drug for depression is considered to be 20 mg per day. In cases of a pronounced depressive state or when developing resistance to treatment in the body, up to 50 mg of the drug is prescribed per day.
  2. The initial dose for obsessive-compulsive disorders is 20 mg per day, then it is adjusted to 40 mg. The maximum daily dose is 60 mg.
  3. In cases of panic attacks, the average therapeutic dose is 40 mg per day. Treatment in this case begins with 10 mg, so as not to cause exacerbations of panic conditions.
  4. Patients suffering from social phobia or undergoing stress are prescribed 20 mg of the substance per day on average. This dose can increase up to 50 mg, depending on the condition of the patient.

People of advanced age, as well as depleted and debilitated patients, are prescribed up to 40 mg of medication per day.

Buy Paroxetine tablets over the counter Cytochrome P-450 CYP2C9 Inhibitors (strength unknown)

Side effects

- From the side of the central nervous system and peripheral nervous system: drowsiness, tremor, asthenia, insomnia, dizziness, fatigue, convulsions, extrapyramidal disorders, serotonin syndrome, hallucinations, mania, confusion, agitation, anxiety, depersonalization, panic attacks, nervousness, amnesia, amnesia . - From the senses: impaired vision. - From the musculoskeletal system: arthralgia, myalgia, muscle weakness, myopathy. - From the urinary system: urinary retention, rapid urination. - From the reproductive system: impaired sexual function, including impotence and ejaculation disorders, hyperprolactinemia / galactorrhea, anorgasmia. - From the digestive system: decreased or increased appetite, taste change, nausea, vomiting, dry mouth, constipation or diarrhea; in some cases, hepatitis. - From the cardiovascular system: orthostatic hypotension. - Allergic reactions: rash, urticaria, ecchymosis, pruritus, angioedema.

Other: increased sweating, rhinitis, hyponatremia, impaired secretion of antidiuretic hormone.

Interaction

Concomitant use with warfarin can cause hemorrhagic syndrome..

Paroxetine should not be taken concomitantly with alcohol.

Concomitant use with sumatriptan, first-class antiarrhythmic drugs (Flecainide and Propafenone), Thioridazine and Fluoxetine increases the risk of side effects.

Primidone and Phenobarbital reduce the bioavailability of the drug. The drug itself inhibits the metabolism of tricyclic antidepressants (desipramine, imipramine, amitriptyline) and astemizole, increasing their blood content and the risk of side effects.

This medicine is incompatible with lithium salts, Tryptophan and MAO inhibitors (including Selegiline, Procarbazine and Furazolid). Antacids do not affect absorption.

Pharmacodynamics and pharmacokinetics

It supports the prolonged activity of central serotonin processes by preventing the uptake of serotonin by brain tissues, which determines its antidepressant effect. The action is effective in the treatment of obsessive-compulsive disorder - OCD, spontaneous panic attacks. Activation properties do not belong to narcotic action and are well tolerated by the circulatory system. The drug does not provoke significant changes in blood pressure, heart rate in a patient.

The medicine to a lesser extent suppresses the antihypertensive effect in comparison with other antidepressants. Treatment of depressive disorders reveals the sufficient effectiveness of a therapeutic agent. The latter is observed in the treatment of patients who do not respond to conventional methods of therapy. Morning medication does not adversely affect the quality and duration of sleep periods.

Clinical studies have shown the inappropriateness of increasing doses of Paroxetine compared with the recommended. However, there is evidence of justification for this for some categories of patients. Regarding the long-term effectiveness of the medication in the treatment of anxiety disorder, there is no officially proven information.

The substance breaks down in the liver, forming inactive metabolites. Active substances of decay are quickly removed from the body, do not have increased pharmacological activity. The main part of the active substance is excreted in urine and bile. Its concentration in the liquid part of the blood increases with liver and kidney dysfunction, in elderly patients.

Dosage

Inside, once a day in the morning, the tablet is swallowed whole, washed down with water. With depression - 20 mg once a day; if necessary, a gradual increase in dose by 10 mg / day, with an interval of at least 1 week, the maximum daily dose is 50 mg. The course of treatment is long. Efficacy is evaluated after 6-8 weeks. In renal and / or liver failure, in elderly and debilitated patients, the initial daily dose is 10 mg, the maximum daily dose is 40 mg. Obsessive-compulsive disorders: the average therapeutic dose is 40 mg / day, if necessary - 60 mg / day. In case of panic disorder, the initial dose is 10 mg / day (to reduce the possible risk of developing exacerbation of panic symptoms), followed by a weekly increase of 10 mg. The average therapeutic dose is 40 mg / day. The maximum dose is 60 mg / day.

What measures are taken in case of an overdose?

First of all, gastric lavage is carried out using activated carbon. Doctors should monitor airway conduction, oxygenation, and lung ventilation.

Continuous monitoring of heart rate and other functions.

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